Beilstein J. Org. Chem.2013,9, 173–179, doi:10.3762/bjoc.9.20
-(ethylsulfonyl)-2-methoxy-1,3-dinitrobenzene (4a) have been precisely physicochemically characterised.
Keywords: angiogenesis; pharmacophoric ligand; synthesisof5-(ethylsulfonyl)-2-methoxyaniline; VEGFR2 tyrosine kinase inhibitors; Introduction
5-(Ethylsulfonyl)-2-methoxyaniline (5) is a starting material
% yield [10]. The synthesisof5-(ethylsulfonyl)-2-methoxyaniline (5) can be utilized for the development of biologically active compounds as well as for different synthetic purposes.
Experimental
1H and 13C NMR spectra were recorded on Varian Gemini (300 MHz and 75 MHz, respectively), chemical shifts are
(SO2CH2), 7.5 (SO2CH2CH3); ESIMS m/z: 290.1 [M]−; Anal. calcd for C9H10N2O7S (290.25): C, 37.24; H, 3.47; N, 9.65; S, 11.05; found: C, 36.89; H, 3.50; N, 9.15; S, 10.97%.
Synthesisof5-(ethylsulfonyl)-2-methoxyaniline (5). 4-(Ethylsulfonyl)-1-methoxy-2-nitrobenzene (4) 6.38 g (26.0 mmol, 1.00 equiv) was
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Graphical Abstract
Figure 1:
The AAZ ligand conformer from PDB complex 1Y6A and its VEGFR2 intermolecular interaction map depict...